The 1978 Texas Southern Tigers football team was an American football team that represented Texas Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 1978 NCAA Division I-AA football season. Led by third-year head coach Wendell Mosley, the Tigers compiled an overall record of 3–7–1, with a mark of 1–4–1 in conference play, and finished sixth in the SWAC. They were outscored by a total of 214 to 131.
Three Texas Southern players were selected to the first team of the District 8 all-star team: John McNeal; Alvin Whittington; and LeRoy Paul.
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